Cardiovascular System

Medical Studies on DHEA – Cardiovascular System

DHEA Cardiovascular System

DHEA also plays an important role in cardiovascular health. For example, in vascular heart disease, it promotes healthy permeability of vessels and can significantly reduce their degree of calcification.

DHEA Supports Heart Health

Many studies have shown that naturally high levels of DHEA reduce the risk of cardiovascular disease by half. This is because DHEA can promote healthy vascular flow and also protects against thrombosis, all important factors for heart health into old age. In studies, low DHEA in women and low DHEA and testosterone in men have been repeatedly linked to an increased risk of heart failure.

Important Cellular Mechanisms

The protective effect of DHEA on cardiovascular health is due, among other things, to the fact that it activates endothelial nitric oxide (eNOX), which is involved as a messenger substance in important vascular processes such as the regulation of blood pressure and the dilation of blood vessels. In addition, studies have identified another mechanism that explains the positive influence of DHEA: By supporting the activation of the PI3K/AKT signaling pathway, DHEA also helps to protect endothelial cells against unhealthy inflammation, a process that plays a special role when it comes to the blood vessels and the heart.

Medical Studies on DHEA – Cardiovascular System

Plasma dehydroepiandrosterone sulfate and cardiovascular disease risk in older men and women

2020-12 Jia X, Sun C, Tang O, Gorlov I, Nambi V, Virani SS, Villareal DT, Taffet GE, Yu B, Bressler J, Boerwinkle E, Windham BG, de Lemos JA, Matsushita K, Selvin E, Michos ED, Hoogeveen RC, Ballantyne CM

Lower dehydroepiandrosterone-sulfate (DHEA-S) levels have been inconsistently associated with coronary heart disease (CHD) and mortality. Data are limited for heart failure (HF) and association between DHEA-S change and events.

Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression

2007-07 Liu D, Si H, Reynolds KA, Zhen W, Jia Z, Dillon JS

The adrenal steroid dehydroepiandrosterone (DHEA) may improve vascular function, but the mechanism is unclear. In the present study, we show that DHEA significantly increased cell viability, reduced caspase-3 activity, and protected both bovine and human vascular endothelial cells against serum deprivation-induced apoptosis.

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