Medical Studies on DHEA – Cancer


Several studies indicate that unhealthy cell growth seems to be directly linked to low DHEA levels. Of course, DHEA cannot cure any type of tumor and should in no way be used as a substitute for established cell therapy. However, in laboratory experiments, some types of unhealthy cell growth have been successfully hindered by DHEA.

DHEA and Breast Cancer

Breast cancer is one of the most common types of cancers in women. Studies have shown that DHEA inhibits the proliferation and migration of breast cancer cells by modulating the cells’ protein expression. Although the exact mechanisms behind this effect are not yet fully understood, it is suspected that DHEA may act on various signaling pathways, such as the PI3K/AKT pathway, which plays a significant role in the proliferation of unhealthy cell growth.

DHEA in Cervical Cancer and Prostate Cancer

Studies have shown that DHEA has a strong inhibitory effect on the proliferation of cervical carcinoma cells. DHEA also appears to have a positive influence on prostate cancer, again via the aforementioned PI3K/AKT pathway.

Medical Studies on DHEA – Cancer

Osteoblasts generate testosterone from DHEA and activate androgen signaling in prostate cancer cells

2021-04 Moon HH, Clines KL, O'Day PJ, Al-Barghouthi BM, Farber EA, Farber CR, Auchus RJ, Clines GA

Bone metastasis is a complication of prostate cancer in up to 90% of men afflicted with advanced disease. Therapies that reduce androgen exposure remain at the forefront of treatment. However, most prostate cancers transition to a state whereby reducing testicular androgen action becomes ineffective.

DHEA inhibits proliferation, migration and alters mesenchymal-epithelial transition proteins through the PI3K/Akt pathway in MDA-MB-231 cells

2021-04 Colín-Val Z, López-Díazguerrero NE, López-Marure R

Cancer is one of the leading causes of death worldwide, and breast cancer is the most common among women. Dehydroepiandrosterone (DHEA), the most abundant steroid hormone in human serum, inhibits proliferation and migration of breast cancer cells, modulating the expression of proteins involved in mesenchymal-epithelial transition (MET). However, the underlying molecular mechanisms are not fully understood. 

Circulating levels of sex steroid hormones and gastric cancer

2021-03 Leal YA, Song M, Zabaleta J, Medina-Escobedo G, Caron P, Lopez-Colombo A, Guillemette C, Camargo MC

Men develop gastric cancer more frequently than women, yet little is known about the mechanisms underlying this sex difference. Sex steroid hormones may influence gastric cancer risk. We therefore assessed whether major circulating adrenal precursors, androgens and estrogens were associated with gastric cancer in a high-risk Mexican population.

Pharmacological activities of dehydroepiandrosterone: a review

2020-01 Sahu P, Gidwani B, Dhongade HJ

Dehydroepiandrosterone (DHEA) is a steroidal hormone secreted by Zonareticularis of the adrenal cortex with a characteristic age related pattern of secretion. These hormones are inactive precursors that are transformed into active sex steroids in peripheral target tissues. These hormones are used for the energy, vitality and the natural support of most bodily functions that involve the endocrine system.

Dehydroepiandrosterone inhibits the proliferation and induces the death of HPV-positive and HPV-negative cervical cancer cells through an androgen- and estrogen-receptor independent mechanism

2009-10 Giron RA, Montano LF, Escobar ML, Lopez-Marure R

Dehydroepiandrosterone (DHEA) has a protective role against epithelial-derived carcinomas; however, the mechanisms remain unknown. We determined the effect of DHEA on cell proliferation, the cell cycle and cell death in three cell lines derived from human uterine cervical cancers infected or not with human papilloma virus (HPV).

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