Bones and Joints

Medical Studies on DHEA – Bones and Joints

DHEA Bones and Joints

Especially in advanced age, bone health, and that of the musculoskeletal system, is an essential factor for lasting quality of life. In this respect, DHEA provides an important contribution and has already proven its worth, both for joint discomfort and for increasing bone density.

DHEA Inhibits Inflammatory Cytokines

Musculoskeletal disorders in old age are among the most common causes of mortality. Therefore, protecting bones and joints is an important task, which DHEA fulfills perfectly by inhibiting proinflammatory cytokines, thus contributing significantly to the improvement of age-related joint discomfort, such as that experienced with osteoarthritis. Studies show that even a few months of treatment with DHEA can produce good results.

Promotion of Healthy Osteoblast Activity

In addition, DHEA also has positive effects when it comes to maintaining healthy bone density. This is because it supports healthy osteoblast activity and increases the expression of insulin-like growth factor I, which has also been shown in several studies to improve fracture healing.

Medical Studies on DHEA – Bones and Joints

Supplementation of dehydroepiandrosterone (DHEA) in pre- and postmenopausal women – position statement of expert panel of Polish Menopause and Andropause Society

2020-01 Rabijewski M, Papierska L, Binkowska M, Maksym R, Jankowska K, Skrzypulec-Plinta W, Zgliczynski W

Dehydroepiandrosterone (DHEA) concentration decreases with age, therefore, DHEA has been considered a hormone that reduces the symptoms associated with aging, so the usefulness of DHEA in premenopausal and postmenopausal women, and the options of hormone therapy have received a large amount of attention.

The effect of long-term DHEA treatment on glucose metabolism, hydrogen peroxide and thioredoxin levels in the skeletal muscle of diabetic rats

2010-05 Jahn MP, Jacob MH, Gomes LF, Duarte R, Araujo AS, Bello-Klein A, Ribeiro MF, Kucharski LC

Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone involved in a number of biological actions. This study shows the effects of DHEA on glucose metabolism, hydrogen peroxide and thioredoxin levels in the skeletal muscle of control and diabetic rats.

Effect of DHEAS on skeletal muscle over the life span: the InCHIANTI study

2004-05 Valenti G, Denti L, Maggio M, Ceda G, Volpato S, Bandinelli S, Ceresini G, Cappola A, Guralnik JM, Ferrucci L

It has been suggested that the reduced production of dehydroepiandrosterone sulfate (DHEAS) may be partially responsible for the decline of muscle strength and mass that often occurs with aging. However, this hypothesis has been only tested in small series of normal volunteers, with little consideration for potential confounders.

Dehydroepiandrosterone (DHEA) as a possible source for estrogen formation in bone cells: correlation between bone mineral density and serum DHEA-sulfate concentration in postmenopausal women, and the presence of aromatase to be enhanced by 1,25-dihydroxyvitamin D3 in human osteoblasts

2002-04 Takayanagi R, Goto K, Suzuki S, Tanaka S, Shimoda S, Nawata H

A significant positive correlation between bone mineral density (BMD) and serum dehydroepiandrosterone sulfate (DHEA-S) was found in 120 postmenopausal women (51–99 years old) but no correlation was seen between BMD and serum estradiol.

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