Medical Studies on DHEA – Immune System
DHEA promotes a strong immune system and also supports the body’s natural defenses against infections. In addition, it has a direct effect on lymphocytes and promotes the healthy production of interleukin-2, an important communication protein involved in immune regulation.
Inflammation-modulating Properties of DHEA
A balanced ratio of DHEA and cortisol is important for a well-functioning immune system. If this ratio is out of kilter, for example, due to too little DHEA and/or too much cortisol, the risk of immune deficiency and autoimmune concerns increases. Studies have shown that DHEA can regulate the body’s inflammatory responses by significantly inhibiting the expression of pro-inflammatory cytokines. In addition, DHEA has been shown to help protect against infection through its modulation of leukocytes, the white blood cells that are part of the innate immune defense system.
In the autoimmune condition lupus erythematosus, a disordered immune system is considered to be a specific cause. The symptoms of lupus are varied and, depending on the type of lupus, range from joint pain and skin changes to inflammation of the internal organs, such as the heart muscle. This autoimmune condition often accompanies certain hormonal changes, such as very low DHEA levels and/or increased cortisol-DHEA quotients, which are almost always detected in those affected.
Medical Studies on DHEA – Immune System
Assessment of DHEAS, cortisol, and DHEAS/cortisol ratio in patients with COVID-19: a pilot study
Dehydroepiandrosterone sulfate (DHEAS) is observed to be decreased in sepsis and inflammatory conditions. In the present study, we assessed the levels of DHEAS and cortisol and the DHEAS/cortisol ratio and their association with inflammatory markers in patients with COVID-19.
The Immunoregulatory Actions of DHEA in Tuberculosis, A Tool for Therapeutic Intervention?
Dehydroepiandrosterone (DHEA) is an androgen synthesized by the adrenal cortex, which is an intermediary in the biosynthesis of sex hormones, such as testosterone and estradiol.
Factors associated with anti-SARS-CoV-2 antibody titres 3 months post-vaccination with the second dose of BNT162b2 vaccine: a longitudinal observational cohort study in western Greece.
Vaccination against SARS-CoV-2 has been extensively deployed during COVID-19 pandemic. One efficient method to evaluate response to vaccination is the assessment of humoral immunity by measuring SARS-CoV-2 antibody titres. We investigated the association between anthropometric parameters (age, body mass index), smoking, diabetes, statin use, hypertension, levels of 25(OH)D and dehydroepiandrosterone sulfate (DHEAS), and SARS-CoV-2 antibody titres after vaccination.
Dehydroepiandrosterone sulfate directly activates protein kinase C-beta to increase human neutrophil superoxide generation
Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in the human circulation and is secreted by the adrenals in an age-dependent fashion, with maximum levels during the third decade and very low levels in old age.
Low serum levels of dehydroepiandrosterone sulfate and testosterone in Albanian female patients with allergic disease
Evidence from several unrelated animal models and some studies conducted in humans, points to the immunomodulatory effects of androgens on various components of the immune system, especially on allergic disorders. This study evaluated the serum concentrations of sex hormones in women with allergy.
Dehydroepiandrosterone attenuates LPS-induced inflammatory responses via activation of Nrf2 in RAW264.7 macrophages
Dehydroepiandrosterone (DHEA) is the major steroid hormone in humans and animals, which can regulate the body's inflammatory responses. However, the detail mechanism of this beneficial function is still poorly understood.
DHEA inhibits leukocyte recruitment through regulation of the integrin antagonist DEL-1
Leukocytes are rapidly recruited to sites of inflammation via interactions with the vascular endothelium. The steroid hormone dehydroepiandrosterone (DHEA) exerts anti-inflammatory properties; however, the underlying mechanisms are poorly understood.
Dehydroepiandrosterone treatment in the aging male – what should the urologist know?
Dehydroepiandrosterone (DHEA) has attracted considerable attention as a means against the decrements of aging. This review will summarize clinical studies evaluating DHEA as a treatment option for age-related conditions and diseases.