Medical Studies on DHEA – Libido

DHEA Libido

Along with estrogen and testosterone, DHEA also plays an important, if not fundamental, role in sexual arousal. This is because this hormonal trio ensures that certain neuronal circuits respond to internal and external stimuli.

Loss of Libido

If a hormonal deficiency, particularly of DHEA, exists, the deficit is associated with significantly reduced sexual activity. Specifically, lower levels of DHEA have been observed in studies of women with Hypoactive Sexual Desire Disorder (HSDD), a loss of female libido. A recent study indicated that this deficiency in DHEA is associated with dysregulation of the hypothalamic-pituitary-adrenal axis, which regulates mood, emotions and stress, among other things. Furthermore, any increase in the cortisol-DHEA ratio has been shown to adversely affect desire, whether it occurs in women or men.

DHEA Increases Sexual Activity

Several studies have shown that supplementation with DHEA increases sexual activity – both before and after menopause. The women participating in one study reported a significant improvement in desire, arousal, lubrication, orgasm and sexual satisfaction. Similar positive effects have been cited in men with a DHEA and/or partial testosterone deficiency after physiological DHEA supplementation.

Medical Studies on DHEA – Libido

Associations between androgens and sexual function in premenopausal women: a cross-sectional study

2020-08 Zheng J, Islam RM, Skiba MA, Bell RJ, Davis SR

Although clinicians often measure the serum concentration of androgens in premenopausal women presenting with sexual dysfunction, with some women given testosterone or dehydroepiandrosterone as treatment if their concentrations are low, whether androgens are determinants of sexual function in women of reproductive age is uncertain. We aimed to clarify the associations between androgens and sexual function in a community-based sample of non-health-care-seeking women.

Supplementation of dehydroepiandrosterone (DHEA) in pre- and postmenopausal women – position statement of expert panel of Polish Menopause and Andropause Society

2020-01 Rabijewski M, Papierska L, Binkowska M, Maksym R, Jankowska K, Skrzypulec-Plinta W, Zgliczynski W

Dehydroepiandrosterone (DHEA) concentration decreases with age, therefore, DHEA has been considered a hormone that reduces the symptoms associated with aging, so the usefulness of DHEA in premenopausal and postmenopausal women, and the options of hormone therapy have received a large amount of attention.

Dehydroepiandrosterone and cortisol as markers of HPA axis dysregulation in women with low sexual desire

2019-06 Basson R, O'Loughlin JI, Weinberg J, Young AH, Bodnar T, Brotto LA

Previous research has found lower serum levels of dehydroepiandrosterone (DHEA) or its sulfated form, DHEA-S, in women diagnosed with Hypoactive Sexual Desire Disorder (HSDD). Given that DHEA and DHEA-S have multiple direct actions on the brain as well as anti-glucocorticoid properties, it is possible that lower levels of DHEA directly impact women's sexual functioning.

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