Dehydroepiandrosterone and age-related musculoskeletal diseases: connections and therapeutic implications
Musculoskeletal disorders related to ageing are one of the most common causes of mortality and morbidity among elderly individuals worldwide.
osteoarthritis (OA)
Medical Studies on DHEA
Suppression of aggrecanase: a novel protective mechanism of dehydroepiandrosterone in osteoarthritis?
Aggrecanase-mediated aggrecan degradation is a significant event in the early stages of osteoarthritis (OA). There has been much interest in the possible role of these aggrecanases, mainly aggrecanase-1 (ADAMTS4) and aggrecanase-2 (ADAMTS5), as therapeutic targets in OA.
The in vitro effects of dehydroepiandrosterone on human osteoarthritic chondrocytes
To investigate the in vitro effects of dehydroepiandrosterone (DHEA) on human osteoarthritic chondrocytes.