dehydroepiandrosterone sulfate

Medical Studies on DHEA

Cortisol to Dehydroepiandrosterone Sulphate ratio and executive function in bipolar disorder

2021-01 Tournikioti K, Alevizaki M, Michopoulos I, Mantzou A, Soldatos C, Douzenis A, Dikeos D, Ferentinos P

Bipolar disorder (BD) is associated with impairment in cognitive domains such as verbal memory and executive functions. Very few studies have assessed dehydroepiandrosterone sulphate (DHEA-S) in BD and its relation to cognitive functioning despite evidence showing its regulatory effects on glucocorticoid action. The aim of our study was to explore the association of cortisol, DHEA-S, and cortisol to DHEA-S ratio with visuospatial memory and executive functioning in BD.

Correlation of age and sex with urine dehydroepiandrosterone sulfate level in healthy Thai volunteers

2021-01 Krorakai K, Tontipattananon S, Leemahanil R, Klangphukhiew S, Wongrathanandha C, Phaibulpanich A, Patramanon R

Dehydroepiandrosterone sulfate (DHEAs), a prohormone secreted by the adrenal gland, plays a role in the synthesis of sex hormones, namely, androgen and estrogen. It has been found that the amount of DHEAs is correlated with age, although most studies have focused on the correlation of serum DHEAs levels with age and sex.

Very High Dehydroepiandrosterone Sulfate (DHEAS) in serum of an overweight female adolescent without a tumor

2020-05 Iliev DI, Braun R, Sánchez-Guijo A, Hartmann M, Wudy SA, Heckmann D, Bruchelt G, Rösner A, Grosser G, Geyer J, Binder G

An increase of serum dehydroepiandrosterone (DHEA) sulfate (DHEAS) is observed in premature adrenarche and congenital adrenal hyperplasia. Very high DHEAS levels are typical for adrenal tumors. Approximately 74% of DHEAS is hydrolyzed to DHEA by the steroid sulfatase (STS). The reverse reaction is DHEA sulfation. Besides these two enzyme reactions, the DHEAS transported through the cell membrane is important for its distribution and excretion.

Dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) in Alzheimer’s disease

2020-01 Strac DS, Konjevod M, Perkovic MN, Tudor L, Erjavec GN, Pivac N

Neurosteroids Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone Sulphate (DHEAS) are involved in many important brain functions, including neuronal plasticity and survival, cognition and behavior, demonstrating preventive and therapeutic potential in different neuropsychiatric and neurodegenerative disorders, including Alzheimer's disease.

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