The therapeutic effect of dehydroepiandrosterone (DHEA) on vulvovaginal atrophy


Wang J, Wang L




Pharmacol Res . 2021 Apr;166:105509.

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Vulvovaginal atrophy (VVA) is a chronic disease that mostly occurs in postmenopausal women. After menopause, insufficient sex hormones affect the anatomy of the vagina and cause drastic physiological changes.

The main histopathological studies of VVA show that postmenopausal estrogen deficiency can lead to the increase of intermediate/parabasal cells, resulting in the loss of lactobacillus, elasticity and lubricity, vaginal epithelial atrophy, pain, dryness.

Although the role of estrogen hormones in the treatment of VVA has always been in the past, it is now widely accepted that it also depends on androgens. Estrogen drugs have many side effects. So, Dehydroepiandrosterone(DHEA)is promising for the treatment of VVA, especially when women with contraindications to estrogen have symptoms.

This review is expected to understand the latest developments in VVA and the efficacy of DHEA.

Copyright © 2021 Elsevier Ltd. All rights reserved.

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